Volume 5, Issue 1, June 2019, Page: 36-41
Differences of Wound Healing in the Buccal Part and Oral Mucosa Labial After Giving Lemongrass Extracts (Cymbopogon ciratus)
Ameta Primasari, Department of Oral Biology, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia
Edikin Raja Sinulingga, Department of Oral Biology, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia
Received: Feb. 3, 2019;       Accepted: May 27, 2019;       Published: Jun. 20, 2019
DOI: 10.11648/j.ijhnm.20190501.16      View  668      Downloads  125
Abstract
Lemongrass is one of the plants that widely used as traditional medicine in Indonesia. Lemongrass contains bioactive substances such as flavonoids, phenolic acids and tannins which act as anti-inflammatory and antioxidants that influence the wound healing process. The aim of this study was to compare the differences in buccal and labial mucosal wound healing, and to see the effect of lemongrass extract on the process of increasing oral mucosal epithelial thickness in white rats. This research is a pure experimental design with a post test-only design with control design. This study used 21 white rats divided into 3 groups where the first group of 100% lemongrass extract, the second group of 50% lemongrass extract, and the third group as the treatment that was not treated. The results of the One-way ANOVA and Post-hoc LSD test on the buccal mucosa showed significant differences with the labial mucosa. There were no significant differences in the buccal section with the second group and the third group p = 0.74 (p <0.05). There were no significant differences in the labial section with the first and second groups, but there were significant differences with the third group p = 0.003 (p <0.05). The effect of lemongrass extract has effectiveness in accelerating healing of oral mucosal wounds in white rats. There was also an increase in the thickness of the oral mucosal epithelium after administration of lemongrass extract with concentrations of 100% and 50%. Based on the research that has been done it can be concluded that healing wounds of the buccal mucosa heal faster than labial mucosal wounds because the buccal part contains saliva which has an important role in the wound healing process.
Keywords
Lemongrass Extract, Wound Healing, Wound Length, Thickness of the Epithelium, Oral Mucosa, White Mice
To cite this article
Ameta Primasari, Edikin Raja Sinulingga, Differences of Wound Healing in the Buccal Part and Oral Mucosa Labial After Giving Lemongrass Extracts (Cymbopogon ciratus), International Journal of Homeopathy & Natural Medicines. Vol. 5, No. 1, 2019, pp. 36-41. doi: 10.11648/j.ijhnm.20190501.16
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Sarlina, Razak AR, Tandah MR. Anti-Bacterial Activity Test Preparations Gel Leaf Extract Citronella (Cymbopogon nardus L. Rendle) against Staphylococcus aureus Bacteria Causes Acne. Galenika J. Pharm. 2017; vol 3 (2): 143-9.
[2]
Ramadhani N, Sumiwi SA. Anti-inflammatory Activity Suspected Various Plants Derived from flavonoids. FarmakaJ. 2014. Vol 14 (1) (suppl); 111-23.
[3]
Nisa VM, Meilawaty Z, Astuti P. Securities Giving Cassava Leaf Extract (Manihotesculenta) Against Wound Healing Process gingiva Rat (Rattus norvegicus). Scientific articles UNEJ Student Research, 2013.
[4]
Sugiaman VK. Improved Wound Healing through the Oral Mucosal administration of Aloe Vera (Linn.) SecaraTopikal. JKM 2011; Vol 11: 70-9.
[5]
Novyana RM, Susianti. Aloe Vera (Aloe Vera) for Wound Healing. Majority J 2016; Vol 5 (4): 149-53.
[6]
Joanna W, Suciati A, Rachmawati M. Improved Buccal Mucosal Epithelium thickness after application Betel Leaf Extract. Maj. Ked. Gi Ind. June 2015; Vol 1 (1): 21-6.
[7]
Polito AJ, Proud D. Eptihelial Cells as Regulators of Airway Inflamation. J Allergy ClinImmunol. 2015 Vol 102 (5); 714-7.
[8]
Wahyudi IA, Magista M, Angel M. Effectiveness of Use Saliva Compared to Povidone-Iodine 10% of the cutaneous wound healing in rats Sprague Dawley. 2014. Vol 1 (1).
[9]
Hairi M, Dewi N, Khatimah H. Effect of Extract Citronella (Cymbopogon Ciratus) against labial mucosa Long Wound Mice In Clinical. Dentino- J. 2016; Vol 1 (2): 197-202.
[10]
MD Nurqadriasti. Test the effectiveness of extracts of lemongrass (Cymbopogon ciratus) to healing cuts on white mice. Dentino- J., 2015.
[11]
Nastity GH, Mukhriani, Mulya RH. Wound Healing Effect Test Sayat kecombrang Leaf Ethanol Extract (Etlingera elatior) Gel Preparations In The Form Of Rabbit (Oryctolagus cuniculus). JF Nikken UINAM. 2015; 3 (2): 54.
[12]
Sewta CA, Mambo C, Wuisan J. Effects Test Leaf Extract Aloe Vera (Aloe Vera L.) Against Skin Incision Wound Healing Rabbit (Oryctolagus cuniculus). Jurnal e-Biomedicine. 2015; 3 (1): 453.
[13]
Puti IR, Melani AM, Hernowo BS, The Role of Topical Leaf Ethanol Extract Noni (Morinda citrifolia L.) In Wound Healing Seen From Imunoekspresi CD34 and collagen in Wistar rats. MKB., 2013; 45 (4): 226.
[14]
Fatimatuzzahroh, Firani NK, Kristianto H. Effectiveness Clove Flower Extract (Syzgium aromaticum) Against Total Vein Capillary On Incision Wound Healing Process Phase Proliferation. FKUB Health magazine. 2015; 2 (2): 92.
[15]
Meena AK, Ruchika G, Subraya BG, Shobha K, KM Anand, Madhur A et al. A Novel Anti-Oxidant Oil Mouth Wash Lemon grass a Clinical trial. Asian Journal of Experimental Biological Sciences 2011; 2 (3) 842-6.
[16]
Francisco V, Figueirinha A, Neves BM, Garcia-Rodriguez C, MC Lopes, Cruz MT et al. Cymbopogon ciratus as a source of new and safe anti-inflammatory drugs: bio-guided assay using lipopolysaccharide-stimulated macrophages. Journal of Ethnopharmacology 2010; 133 (2): 818-27.
[17]
Garcia R, Pinto-Ferreira J, Santos T, Costa G, Caramona M, T Batista et al. Evaluation of anti-inflammatory and analgesic activities of Cymbopogon ciratus on in vivo models. European Congress of Pharmacology 2012; 6: 120.
[18]
Wahyudi IA, Magista M, Angel M. Effectiveness of Use Saliva Compared to Povidone-Iodine 10% of the cutaneous wound healing in rats Sprague Dawley. 2014. Vol 1 (1).
[19]
Provision of the ointment Winny A. noni leaf extract (Morinda citrifolia) improve the regeneration of injured tissue in males R. norvegicus [thesis]. Denpasar: Udayana University; 2013.
[20]
Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin. Dermatol. 2007; 25: 9-18.
[21]
BF Prasetyo, Wientarsih I, Priosoeryanto BP. Activities extract gel banana tree trunk in the process of wound healing in mice. Veterinary Journal. 2010; 11 (2): 70-3.
[22]
Jain S. Dermatology. Journal of Ilustrated Study Guide and Comprehensive Board Review. 2012: 2-10.
[23]
Soni H, Sighai AK. A recent update of botanicals for wound healing activity. IRJP. 2012; 3: 1-6.
[24]
Thakur R, Jain N, Pathak R, and SS Sandhu. Practices in Wound Healing Studies of Plants. Evidence-Based Complementary and Alternative Medicine 2011: 1-15.
[25]
Nayak BS, Sandiford S, and Maxwell A. Evaluation of the Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf. Evidence Based Complement Alternative Medicine 2007; 6 (3): 351-6.
[26]
Li K, Diao Y, Zhang H, Wang S, Zhang Z, Yu B, et al. Tannin extracts from immature fruits of Terminalia chebula fructus retz. Cutaneous promote wound healing in rats. BMC Complement Med alternat. 2011; 11: 86.
[27]
Pastar I, Stojadinovic O, Yin NC, Ramirez H, Aron G, Nusbaum et al. Epithelization in wound healing: A comprehensive review. Wound Healing Society., 2013; 3 (7): 445-64.
[28]
Rupina W, Trianto HF, Fitrianingrum I. Effect of 70% Ethanol Extract Ointment Leaf Re-eptelisasi Karamunting Against Skin Incision Wound Wistar rats. Research article. 2016; 4 (1): 26.
[29]
Z. Meilawaty Gum Extracts Test Biduri (Calotropis gigantea) Gingival Fibroblasts Cells Against Wistar rats In Wound Healing. Prodenta Journal., 2013; 1 (2): 71-7.
Browse journals by subject